Aquaporin Positron Emission Tomography Differentiates Between Grade III and IV Human Astrocytoma

作者：Suzuki Yuji^*; Nakamura Yukihiro; Yamada Kenichi; Kurabe Satoshi; Okamoto Kouichirou; Aoki Hiroshi; Kitaura Hiroki; Kakita Akiyoshi; Fujii Yukihiko; Huber Vincent J; Igarashi Hironaka; Kwee Ingrid L; Nakada Tsutomu

来源：Neurosurgery, 2018, 82(6): 842-846.

DOI：10.1093/neuros/nyx314

• Aquaporin1 (AQP1)
• Aquaporin4 (AQP4)
• Astrocytoma
• [11C]TGN-020
• Positron emission tomography (PET)

BACKGROUND: Aquaporin (AQP) water channels play a significant role in mesenchymal microvascular proliferation and infiltrative growth. AQPs are highly expressed in malignant astrocytomas, and a positive correlation is observed between their expression levels and histological tumor grade.
OBJECTIVE: To examine the utility of aquaporin positron emission tomography (PET) for differentiating between astrocytoma grade III and grade IV using the AQP radioligand [C-11] TGN-020.
METHODS: Fifteen astrocytoma patients, grade III (n = 7) and grade IV (n = 8), and 10 healthy volunteers underwent [C-11] TGN-020 aquaporin PET imaging. Surgical tissues of astrocytoma patients were examined for histopathological grading using the WHO classification standard and expression of AQP1 and AQP4 immunohistochemically.
RESULTS: Mean standardized uptake values of astrocytoma grade III and IV (0.51 +/- 0.11 vs 1.50 +/- 0.44, respectively) were higher than normal white matter (0.17 +/- 0.02, P <.001) for both tumor grades. Importantly, mean standardized uptake values of astrocytoma grade IV were significantly higher than grade III (P <.01).
CONCLUSION: Our study demonstrated that [C-11] TGN-020 aquaporin PET imaging differentiated between astrocytoma grades III and IV. We suggest its clinical application as a noninvasive diagnostic tool would lead to advancements in the management of these malignant brain tumors.

• 出版日期2018-6