A novel series of 2,5-disubstituted 1,3,4-thiadiazoles as potential anticonvulsant agent

作者：Rajak Harish^*; Behera Chinmay K; Pawar Rajesh S; Singour Pradeep K; Kharya Murli Dhar

来源：Chinese Chemical Letters, 2010, 21(10): 1149-1152.

DOI：10.1016/j.cclet.2010.04.012

• 1,3,4-Thiadiazoles
• Semicarbazones
• Anticonvulsant activity

In pursuit for better antiepileptic drug and the importance of semicarbazones and 2,5-disubstituted 1,3,4-thiadiazoles as anticonvulsant pharmacophore, a series of novel N-({5-[(6-methyl-1-benzofuran-3-yl)methyl]-1,3,4-thiadiazol-2-yl}carbamothioyl)-2/3/4-substitutedbenzamide were designed, synthesized and evaluated for their anticonvulsant activity. The findings of the present studies confirmed that the pharmacophore model with four binding sites is crucial for anticonvulsant activity. Structure activity relationships among synthesized compounds were also established.

• 出版日期2010-10