The effect of palonosetron on rocuronium-induced withdrawal movement

作者：Park Ki Bum; Jeon Younghoon; Yi Junggu; Kim Ji hyun; Chung Seung Yeon; Kwak Kyung Hwa^*

来源：Revista Brasileira de Anestesiologia, 2017, 67(4): 337-341.

DOI：10.1016/j.bjane.2016.04.002

• Palonosetron
• Rocuronium
• Injection
• Pain
• Withdrawal movement

Background: Rocuronium causes pain and withdrawal movement during induction of anesthesia. In this study, palonosetron was investigated to have analgesic effect on the reduction of rocuronium-induced withdrawal movement.
Methods: 120 patients were randomly assigned to one of three groups to receive either saline, lidocaine 20 mg, or palonosetron 0.075 mg with a tourniquet applied two minutes before thiopental sodium (5 mg.kg(-1)) was given intravenously. After loss of consciousness, rocuronium (0.6 mg.kg(-1)) was injected and the withdrawal movement was estimated by 4-point scale in a double-blind manner.
Results: The overall incidence of rocuronium withdrawal movement was 50% with lidocaine (p = 0.038), 38% with palonosetron (p = 0.006) compared with 75% for saline. The incidence of no pain to mild pain was significantly lower in the lidocaine and palonosetron groups (85% and 92% respectively) than in the saline group (58%). However, there was no significant difference in withdrawal movement between the lidocaine and palonosetron groups. There was no severe movement with palonosetron.
Conclusion: Pretreatment of palonosetron with venous occlusion may attenuate rocuronium-induced withdrawal movement as effective as the use of lidocaine. It suggested that peripheral action of palonosetron was effective to reduce rocuronium-induced withdrawal movement.

• 出版日期2017-8