Anticancer activity of N-bis(trifluoromethyl)alkyl-N '-(polychlorophenyl) and N '-(1,2,4-triazolyl) ureas

作者：Luzina Elena L^*; Popov Anatoliy V

来源：European Journal of Medicinal Chemistry, 2010, 45(11): 5507-5512.

DOI：10.1016/j.ejmech.2010.08.057

• Fluorinated ureas
• Anticancer activity
• Synthesis

A number of N-bis(trifluoromethyl)alkyl-N'-substituted ureas have been synthesized and evaluated for their in vitro anticancer activity against the human cancer cell lines at the National Cancer Institute (NCI, USA). Marked activity was shown for compounds 4a and 5a. The most sensitive cell lines relative to the tested compounds were: 4a UO-31 (renal cancer, log GI(50) -5.62), HS 578T (breast cancer, log GI(50) -5.50), 5a HCC-2998 (colon cancer, log GI(50) -5.94), NCI-H322M (lung cancer, log GI(50) -5.75) and PC-3 (prostate cancer, log GI(50) -5.66).

• 出版日期2010-11