Antinociceptive and anti-inflammatory activity of Sambucus palmensis link, an endemic Canary Island species

作者：Abdala Susana^*; Devora Sandra; Martin Herrera Domingo; Perez Paz Pedro

来源：Journal of Ethnopharmacology, 2014, 155(1): 626-632.

DOI：10.1016/j.jep.2014.06.002

• Sambucus palmensis
• Antinociceptive activity
• Anti-inflammatory activity
• Medicinal plant
• Folk medicine

Ethnopharmacological relevance: Sambucus palmensis Link is an endemic species of the Canary Islands, popularly known as %26quot;Sauco canario%26quot;. This species has wide use in folk medicine practice on the islands, especially as analgesic and anti-inflammatory. So the aim of our study is to evaluate the antinociceptive and anti-inflammatory activity of an aqueous extract of this species. %26lt;br%26gt;Materials and methods: Three aqueous extract doses (35, 52.5 and 70 mg/kg) were orally administered to laboratory Swiss mice obtained from the Central Animal House of La Laguna University. Writhing responses induced by phenylquinone, formalin induced paw pain response, tail-flick test and paw edema induced by carrageenan were evaluated in this work. %26lt;br%26gt;Results: Oral pretreatment with 52.5 and 70 mg/kg Sambucus palmensis aqueous extract significantly reduced the writhing number induced by phenylquinone injection (61.64 and 89.04% respectively), and the pain response in the first (36.67 and 38.89%) and second (57.28 and 70.1%) phases respectively of the formalin test. Sambucus palmensis had a very slight effect on tail-flick test and inhibited moderately the edema formation induced by carrageenan in mice. %26lt;br%26gt;Conclusions: These data show for the first time that Sambucus palmensis has a significant antinociceptive effect that seems to be more peripherical than central. Sambucus palmensis also displays a moderate anti-inflammatory activity in an acute inflammation model. These results support the widespread use of Sambucus palmensis in popular medicine to treat pain and inflammation.

• 出版日期2014-8-8