Disposition of firocoxib in late pregnant and early postpartum mares

作者：Giguere S^*; Macpherson M L; Benson S M; Cox S; McNaughten J W; Pozor M A

来源：Journal of Veterinary Pharmacology and Therapeutics, 2016, 39(2): 196-198.

DOI：10.1111/jvp.12253

Pregnancy induces several physiologic changes that might impact the bioavailability, distribution, metabolism, and excretion of drugs. The objective of this study was to determine the effects of pregnancy on the disposition of oral firocoxib in mares. Seven pony mares received oral firocoxib paste at a dose of 0.1mg/kg during late pregnancy and again 12 to 33days postpartum. Firocoxib concentrations were measured in plasma by HPLC with ultraviolet detection. Maximum plasma concentrations were significantly lower in pregnant (50.0 +/- 21.8ng/mL) than in postpartum (73.7 +/- 25.6ng/mL) mares. Plasma concentrations 24h after administration, time to maximum plasma concentrations, and area under the plasma concentration versus time curve were not significantly different between late pregnancy and the postpartum period in mares.

• 出版日期2016-4