Adaptive diversity of innate immune receptor family short pentraxins in Murinae

作者：Li, Yan^*; Robins, Judith H.; Ye, Jianping; Huang, Zhiyong; Wen, Qiang; Zhang, Guojie

来源：FEBS LETTERS, 2012, 586(6): 798-803.

DOI：10.1016/j.febslet.2012.01.048

• Short pentraxin
• Adaptive diversity
• Ligand-binding region
• Subunit contact region
• Murinae

The short pentraxins C-reactive protein (CRP) and serum amyloid P component (SAP) constitute a group of innate immune receptors that trigger immune activation by detecting molecules of the microbial cell wall. Here, we examined the evolution of short pentraxins in Murinae lineages. By molecular evolutionary analysis, CRP and SAP have been experiencing rapid diversification, driven by adaptive selection. Further, our protein modeling demonstrates that adaptively selected amino acids lie in the ligand-binding region and contact region between subunits. Our findings suggest that rapid diversification of these regions could contribute to the determinants of recognizing specificity and the interaction between subunits.

• 出版日期2012-3-23
• 单位绍兴文理学院; 深圳华大生命科学研究院; 四川农业大学