Mechanisms of hepatic fibrogenesis

作者：Lee Ursula E; Friedman Scott L^*

来源：Best Practice & Research in Clinical Gastroenterology, 2011, 25(2): 195-206.

DOI：10.1016/j.bpg.2011.02.005

• Stellate cell
• Fibrogenesis
• Tyrosine kinase
• Growth factors
• Immune cells
• Adipokines

Multiple etiologies of liver disease lead to liver fibrosis through integrated signaling networks that regulate the deposition of extracellular matrix. This cascade of responses drives the activation of hepatic stellate cells (HSCs) into a myofibroblast-like phenotype that is contractile, proliferative and fibrogenic. Collagen and other extracellular matrix (ECM) components are deposited as the liver generates a wound-healing response to encapsulate injury. Sustained fibrogenesis leads to cirrhosis, characterized by a distortion of the liver parenchyma and vascular architecture. Uncovering the intricate mechanisms that underlie liver fibrogenesis forms the basis for efforts to develop targeted therapies to reverse the fibrotic response and improve the outcomes of patients with chronic liver disease.

• 出版日期2011-4