Application of a method used to deconstruct a single dose pharmacokinetic profile from multiple dose data

作者：Stockmann Chris^*; Spigarelli Michael G; Healy Daniel P; Gottschlich Michele M; Kagan Richard; Balch Alfred H; Sherwin Catherine

来源：Biopharmaceutics & Drug Disposition, 2015, 36(6): 405-409.

DOI：10.1002/bdd.1949

• pharmacokinetics
• curve stripping
• exponential
• parameter estimation

With traditional non-compartmental methods, it is challenging to deconstruct plasma concentration versus time curves to assess the influence of individual doses. This study describes the application of a mathematical approach used to deconstruct a single dose curve using data derived from the second, third, fourth or nth dosing interval. Using data from a prospective clinical trial it is demonstrated that this approach reliably estimates pharmacokinetic parameters measured following two doses of zolpidem tartrate. Additionally, the study demonstrates the application of this approach using previously published data from a single- and multiple-dose pharmacokinetic study of the antibiotic gatifloxacin.

• 出版日期2015-9