Antimicrobial activity and phenolic content of natural site and micropropagated Limonium avei (De Not.) Brullo %26 Erben plant extracts

作者：Nostro Antonia^*; Filocamo Angela; Giovannini Annalisa; Catania Stefania; Costa Chiara; Marino Andreana; Bisignano Giuseppe

来源：Natural Product Research, 2012, 26(22): 2132-2136.

DOI：10.1080/14786419.2011.628669

• Limonium avei
• halophytic plant
• antimicrobial activity
• phenolic acids
• flavonoids

This study reported the antimicrobial activity and phenolic content of natural site and micropropagated Limonium avei (De Not.) Brullo %26 Erben inflorescences. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of ethanolic extracts were determined according to the Clinical Laboratory Standards Institute guidelines. Individual phenolic acids and flavonoids were detected by a high performance liquid chromatography (HPLC-DAD) method. The samples showed a comparable antimicrobial activity, although the natural site extract possessed the lower MIC values. The best activity was detected against Gram-positive bacteria, such as Staphylococcus aureus including methicillin resistant strains (MIC and MBC values ranging from 7.81 to 62.50 mu g mL(-1) and from 500 to 2000 mu g mL(-1) respectively). In contrast, a low activity was found on Gram-negative bacteria and Candida albicans. The HPLC-DAD analysis revealed ten phenolic acids and four flavonoids with a major amount of m-coumaric acid, naringin and quercetin in the natural site extract.

• 出版日期2012