A genome-wide association study of prostate cancer in West African men

作者：Cook Michael Blaise^*; Wang Zhaoming; Yeboah Edward D; Tettey Yao; Biritwum Richard B; Adjei Andrew A; Tay Evelyn; Truelove Ann; Niwa Shelley; Chung Charles C; Chokkalingam Annand P; Chu Lisa W; Yeager Meredith; Hutchinson Amy; Yu Kai; Rand Kristin A; Haiman Christopher A; Hoover Robert N; Hsing Ann W; Chanock Stephen J

来源：Human Genetics, 2014, 133(5): 509-521.

DOI：10.1007/s00439-013-1387-z

Age-adjusted mortality rates for prostate cancer are higher for African-American men compared with those of European ancestry. Recent data suggest that West African men also have elevated risk for prostate cancer relative to European men. Genetic susceptibility to prostate cancer could account for part of this difference. We conducted a genome-wide association study (GWAS) of prostate cancer in West African men in the Ghana Prostate Study. Association testing was performed using multivariable logistic regression adjusted for age and genetic ancestry for 474 prostate cancer cases and 458 population-based controls on the Illumina HumanOmni-5 Quad BeadChip. The most promising association was at 10p14 within an intron of a long non-coding RNA (lncRNA RP11-543F8.2) 360 kb centromeric of GATA3 (p = 1.29E-7). In sub-analyses, SNPs at 5q31.3 were associated with high Gleason score (a parts per thousand yen7) cancers, the strongest of which was a missense SNP in PCDHA1 (rs34575154, p = 3.66E-8), and SNPs at Xq28 (rs985081, p = 8.66E-9) and 6q21 (rs2185710, p = 5.95E-8) were associated with low Gleason score (< 7) cancers. We sought to validate our findings in silico in the African Ancestry Prostate Cancer GWAS Consortium, but only one SNP, at 10p14, replicated at p < 0.05. Of the 90 prostate cancer loci reported from studies of men of European, Asian or African-American ancestry, we were able to test 81 in the Ghana Prostate Study, and 10 of these replicated at p < 0.05. Further genetic studies of prostate cancer in West African men are needed to confirm our promising susceptibility loci.

• 出版日期2014-5