Asymmetric beta-boration of alpha,beta-unsaturated carbonyl compounds with chiral Rh[bis(oxazolinyl)phenyl] catalysts

作者：Toribatake Kenji; Zhou Li; Tsuruta Ayae; Nishiyama Hisao^*

来源：Tetrahedron, 2013, 69(17): 3551-3560.

DOI：10.1016/j.tet.2013.02.086

• Asymmetric
• Rhodium
• Bis(oxazoline)
• Boration
• Conjugate addition

Chiral rhodium[bis(oxazolinyl)phenyl] complexes exhibited high catalytic activity for the beta-boration of alpha,beta-unsaturated esters, ketones, and amides with bis(pinacolato)diboron in the presence of sodium tertbutoxide to attain high enantioselectivity of up to 97%. The substrate scope and catalytic mechanism were discussed.

• 出版日期2013-4-29