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摘要
A high-performance liquid chromatography-electrospray ionization-mass spectromentry (LC-ESI-MS) method has been developed for the determination of picroside II in dog plasma. Plasma samples were deproteinated with acetonitrile and a Hypersil ODS2 column was used with a mobile phase consisted of methanol-water. The determination was validated in the concentration range of 0.10-50 mu g mL(-1) using 50 mu L of plasma. The method was successfully applied to a pharmacokinetic study of picroside II.
