Membrane-bound estrogen receptor-alpha expression and epidermal growth factor receptor mutation are associated with a poor prognosis in lung adenocarcinoma patients

作者：Shimizu Katsuhiko^*; Hirami Yuji; Saisho Shinsuke; Yukawa Takuro; Maeda Ai; Yasuda Koichiro; Nakata Masao

来源：World Journal of Surgical Oncology, 2012, 10: 141.

DOI：10.1186/1477-7819-10-141

• Membrane-bound estrogen receptor-alpha
• Epidermal growth factor receptor mutation
• Lung adenocarcinoma

Background: The purpose of this study is to clarify the correlations between the expression of membrane-bound estrogen receptor-alpha (mER alpha) and epidermal growth factor receptor (EGFR) mutation and clinicopathological factors, especially in relation to the prognosis, in patients with lung adenocarcinoma.
Methods: We conducted a retrospective review of the data of 51 lung adenocarcinoma patients with tumors measuring less than 3 cm in diameter. Immunohistochemical staining for mER alpha expression and detection of the EGFR mutation status were performed.
Results: Among the 51 patients, the tumors in 15 showed both mER alpha expression and EGFR mutation. ("double positive") Significant associations between "double positive" and vascular invasion, vascular endothelial growth factor expression, and Ki-67 expression were observed. A multivariate analysis revealed that only "double positive" was an independent risk factor influencing the recurrence-free survival.
Conclusions: Presence of mER alpha expression together with EGFR mutation was found to be an independent prognostic factor for survival in patients with lung adenocarcinoma, suggesting cross-talk between mER alpha and EGFR mutation.

• 出版日期2012-7-11