Durable clinical activity of single-agent bevacizumab in a nonagenarian patient with metastatic alveolar soft part sarcoma

作者：Mir Olivier^*; Boudou Rouquette Pascaline; Larousserie Frederique; Blanchet Benoit; Babinet Antoine; Anract Philippe; Goldwasser Francois

来源：Anti-Cancer Drugs, 2012, 23(7): 745-748.

DOI：10.1097/CAD.0b013e3283514b8c

• alveolar soft part sarcoma
• angiogenesis inhibitors
• bevacizumab
• sarcoma
• soft tissue sarcoma
• sunitinib
• vascular endothelial growth factor-A

Alveolar soft part sarcoma is a rare malignancy usually considered resistant to conventional chemotherapy, but recent data suggest that the multikinase inhibitors sunitinib and cediranib could be active in this setting. A 90-year-old lady with alveolar soft part sarcoma of the leg and lung metastases was started on sunitinib 37.5 mg daily. The treatment was poorly tolerated with grade 3 hypertension and grade 3 thrombocytopenia, which persisted after dose reduction to 25 mg daily. The patient was subsequently started on bevacizumab 10 mg/kg every 2 weeks, resulting in a marked improvement in pain and a partial response on lung metastases for 16 months and ongoing. Agents targeting the vascular endothelial growth factor-signalling pathway seem to exert clinically relevant and prolonged activity against alveolar soft part sarcoma and deserve further evaluation in the treatment of this rare soft tissue sarcoma.

• 出版日期2012-8