Affinity sensor based on immobilized molecular imprinted synthetic recognition elements

作者：Lenain Pieterjan^*; De Saeger Sarah; Mattiasson Bo; Hedstrom Martin

来源：Biosensors and Bioelectronics, 2015, 69: 34-39.

DOI：10.1016/j.bios.2015.02.016

• Molecularly imprinted polymer
• Capacitive affinity sensor
• Monitoring
• sensors
• Analytical methods
• Metergoline

An affinity sensor based on capacitive transduction was developed to detect a model compound, metergoline, in a continuous flow system. This system simulates the monitoring of low-molecular weight organic compounds in natural flowing waters, i.e. rivers and streams. During operation in such scenarios, control of the experimental parameters is not possible, which poses a true analytical challenge. A two-step approach was used to produce a sensor for metergoline. Submicron spherical molecularly imprinted polymers, used as recognition elements, were obtained through emulsion polymerization and subsequently coupled to the sensor surface by electropolymerization. This way, a robust and reusable sensor was obtained that regenerated spontaneously under the natural conditions in a river. Small orga

• 出版日期2015-7-15