Autoantibodies to neurofascin-186 and gliomedin in multifocal motor neuropathy

作者：Notturno Francesca^*; Di Febo Tiziana; Yuki Nobuhiro; Rodriguez Blanca M Fernandez; Corti Davide; Nobile Orazio Eduardo; Carpo Marinella; De Lauretis Angelo; Uncini Antonino

来源：Journal of Neuroimmunology, 2014, 276(1-2): 207-212.

DOI：10.1016/j.jneuroim.2014.09.001

• Chronic inflammatory demyelinating neuropathy
• Gliomedin
• Neurofascin
• Multifocal motor neuropathy

We tested autoantibodies to neurofascin-186 (NF186) and gliomedin in sera from patients with multifocal motor neuropathy (MMN, n = 53) and chronic inflammatory demyelinating polyneuropathy (CIDP, n = 95) by ELISA. IgG antibodies to NF186 or gliomedin were found in 62% of MMN and 1% of CIDP sera, and IgM antibodies to the same antigens in 12% of MMN and 1% of CIDP sera. These autoantibodies activated complement. Ten percent of the MMN sera without IgM anti-GM1 reactivity had anti-NF186 antibodies. Because NF186 and gliomedin play a crucial role for salutatory conduction, the autoantibodies may contribute to produce motor nerve conduction block and muscle weakness in MMN.

• 出版日期2014-11-15