Development of thiol-responsive amide bond cleavage device and its application for peptide nucleic acid-based DNA releasing system

作者：Shigenaga Akira^*; Yamamoto Jun; Hirakawa Hiroko; Ogura Keiji; Maeda Nami; Morishita Ko; Otaka Akira

来源：Tetrahedron Letters, 2010, 51(18): 2525-2528.

DOI：10.1016/j.tetlet.2010.03.006

To develop a thiol-responsive DNA-releasing system, a thiol-responsive amino acid capable of inducing an amide bond cleavage in the presence of a thiol was developed. It was successfully combined with peptide nucleic acid (PNA), and thiol-induced release of DNA from the thiol-responsive PNA/DNA complex was observed.

• 出版日期2010-5-5