Development of dispersive liquid-liquid microextraction technique using ternary solvents mixture followed by heating for the rapid and sensitive analysis of phthalate esters and di(2-ethylhexyl) adipate

作者：Farajzadeh Mir Ali^*; Khoshmaram Leila

来源：Journal of Chromatography A, 2015, 1379: 24-33.

DOI：10.1016/j.chroma.2014.12.049

• Dispersive liquid-liquid microextraction
• Ternary solvents mixture
• Simplex centroid experimental design
• Gas chromatography
• Phthalate esters

In this study, for the first time, a dispersive liquid-liquid microextraction technique using a ternary solvent mixture is reported. In order to extract five phthalate esters and di(2-ethylhexyl) adipate with different polarities from aqueous samples, a simplex centroid experimental design method was used to select an optimal mixture of ternary solvents prior to gas chromatographyflame ionization detection. In this work, dimethyl formamide as a disperser solvent containing dichloromethane, chloroform, and carbon tetrachloride as a ternary extraction solvent mixture is injected into sample solution and a cloudy solution is formed. After centrifuging, 250 mu L of the obtained sedimented phase was transferred into another tube and 5 mu L DMF was added to it. Then, the tube was heated in a water bath at 75 degrees C for 5 min in-order to evaporate the main portion of the extraction solvents. Finally, 2 mu l. of the remained phase is injected into the separation system. Under the optimum extraction conditions, the method shows wide linear ranges and low limits of detection and quantification between 0.03-0.15 and 0.09-0.55 mu g L-1, respectively. Enrichment factors and extraction recoveries are in the ranges of 980-4500 and 20-90%, respectively. The method is successfully applied in the determination of the target analytes in mineral water, soda, lemon juice, vinegar, dough, and yogurt packed in plastic packages.

• 出版日期2015-1-30