Neurochemical dementia diagnostics: assays in CSF and blood

作者:Lewczuk Piotr; Hornegger Joachim; Zimmermann Ruediger; Otto Markus; Wiltfang Jens; Kornhuber Johannes*
来源:European Archives of Psychiatry and Clinical Neuroscience, 2008, 258: 44-49.
DOI:10.1007/s00406-008-5005-3

摘要

In this review, current neurochemical dementia diagnostics (NDD) procedures are presented with a focus on biomarkers in the cerebrospinal fluid (CSF) and blood: amyloid P peptides, tau protein, and its phosphorylated form (pTau). CSF analysis is an increasingly important tool for early and differential diagnosis of dementia syndromes. Although lumbar puncture is a mildly invasive procedure with a low incidence of complications, establishing blood assays capable of reliably measuring NDD biomarkers is an aim of several studies worldwide.

  • 出版日期2008-11