A Novel Ratiometric Fluorescent Probe for Cyanide Anion with High Selectivity and Its Application in Cell Imaging

作者：Feng Yusha; Bai Lifei; Wang Shaodan; Kong Xiangyi; Cong Lele; Zhao Qing^*; Yang Qingbiao; Li Yaoxian

来源：Chemical Research in Chinese Universities, 2017, 33(4): 534-539.

DOI：10.1007/s40242-017-7036-7

• Ratiometric fluorescence
• Cyanide
• Nucleophilic addition
• Bioimaging

A novel hybrid acenaphthene-hemicyanine dye(Acc) was designed and synthesized as a colorimetric and ratiometric fluorescent sensor for cyanide detection. The nucleophilic addition of cyanide anion resulted in the blocking of the intramolecular charge transfer(ICT). Thus, the sensor exhibited high sensitivity and selectivity towards cyanide anion among many anions in dimethylsulphoxide(DMSO)-water media, with the emission wavelength displaying a very large shift(186 nm). Moreover, the color changes of the solution could be observed by the naked eyes and it had a short response time. Under optimized conditions, the detection limit for cyanide was calculated to be 1.3 mu mol/L(R-2=0.9958). In addition, the probe had excellent biocompatibility and could be utilized to monitor cyanide in living cells.

• 出版日期2017-8
• 单位吉林大学