Age, atherosclerosis and type 2 diabetes reduce human mesenchymal stromal cell-mediated T-cell suppression

作者：Mancini Ozge Kizilay; Shum Tim Dominique; Stochaj Ursula; Correa Jose A; Colmegna Ines^*

来源：Stem Cell Research & Therapy, 2015, 6(1): 140.

DOI：10.1186/s13287-015-0127-9

To this end human MSCs were isolated from adipose tissue and the MSC:CD4(+) T-cell suppression was assessed in a co-culture system. In summary, this study demonstrates that advanced age, atherosclerosis and type 2 diabetes mellitus reduce the functional potency of MSCs. Optimizing the criteria for the selection of MSC donors could enhance the results of cell-based therapies.

• 出版日期2015-8-8