Accuracy of TOMPOOL (gated blood pool SPECT processing software) for the assessment of bi-ventricular volumes and ejection fraction

作者：Dercle L^*; Pascal P; Giraudmaillet T; Ouali M; Lairez O; Marachet M A; Rousseau H; Sinigaglia M; Aziz A L; Bastie D; Berry I

来源：Medecine Nucleaire-Imagerie Fonctionnelle et Metabolique, 2015, 39(4): 371-379.

DOI：10.1016/j.mednuc.2015.04.002

• Ventriculography
• MRI
• Catheter measurement
• Reproducibility
• Diagnostic accuracy

Background. - To evaluate the diagnostic accuracy of TOMPOOL (gated blood pool SPECT). Comparison with a reference-algorithm: BP-SPECT. Comparison with MRI and right heart catheter measurement. Estimation of the inter-observer reproducibility.
Methods and results. - Ninety-nine consecutive patients underwent GBPS and two physicians performed the measurement using TOMPOOL and BP-SPECT. Results were compared to the recommended reference-standard: cardiac magnetic resonance imaging [CMR] (EDV, ES'V, EF, n = 35), catheter measurements from thermodilution [TD] (CO, n = 21).
Results. - Results are always referred using the following order: correlation with BP-SPECT (n = 99), correlation with reference-standard (MRI or right heart catheter measurement), inter-observer correlation. RVEF: r = 0.67; r = 0.70; r = 0.81. RVEDV: r = 0.74; r = 0.49; r = 0.77. RVESV: r = 0.76; r = 0.64; r = 0.81. RCO: r = 0.68; 0.63; 0.78. LVEF: r = 0.88; r = 0.79; r = 0.94. LVEDV: r = 0.82; r = 0.80; r = 0.90. LVESV: r = 0.89; r = 0.90; 0.95.
Conclusion. - TOMPOOL allows a quantitative and qualitative analysis of the volume and systolic function of the left ventricle. However, a prior CMR-based calibration is preferable (thresholds must be adjusted). A qualitative analysis of the right ventricle is more reliable (poorer correlation and reproducibility).

• 出版日期2015-9