Antinociceptive activity of steroid alkaloids isolated from Solanum trilobatum Linn.

作者：Pandurangan Annamalai^*; Khosa Ratan Lal; Hemalatha Siva

来源：Journal of Asian Natural Products Research, 2010, 12(8): 691-695.

DOI：10.1080/10286020.2010.497997

• solasodine
• analgesic activity
• formalin test
• hot plate test
• writhing test

Solasodine (1) was isolated for the first time from the roots of Solanum trilobatum Linn., a member of the Solanaceae, and assessed for its presumed antinociceptive activity using several experimental murine models, viz. the writhing, formalin, and hot plate tests. When used at doses of 2, 4, and 8mg/kg, this steroidal alkaloid caused a significant and dose-dependent decrease in the nociception induced by an intraperitoneal injection of acetic acid (p0.001). It also led to a significant reduction of the painful sensation caused by formalin in both phases of the formalin test (p0.001). Furthermore, the alkaloid produced a significant increase in the reaction time in the hot plate test (p0.001). These results suggest that solasodine elicited antinociceptive activity through both central and peripheral mechanisms.

• 出版日期2010