科研之友
微信
新浪微博
Facebook
分享链接
摘要
Background: Naturalistic studies can be useful tools to understand how an intervention works in the real clinical practice. This study aims to investigate the outcomes in a naturalistically treated depressed inpatients cohort, who were referred, or not, to unilateral ECT. Methods: Depressed adults according to MINI admitted in a psychiatric unit were divided in unilateral ECT treated and non-ECT treated. Main outcomes were: depression improvement in Hamilton Rating Scale for Depression (HDRS-17) scores; response (HDRS-17 improvement >= 50 %); remission (HDRS-17 score <= 7); length of hospitalization. Results: Forty-three patients were included in unilateral ECT group and 104 in non-ECT group. No differences of psychotic symptoms, melancholic features or past maniac episode were found between groups. Unilateral ECT group had a mean HDRS-17 score higher than non-ECT group at admission (ECT: 25.05 +/- 1.03; non-ECT: 21.61 +/- 0.69; p = 0.001), but no significant difference was found at discharge (ECT: 7.70 +/- 0.81; non-ECT: 7.40 +/- 0.51; p = 0.75). Unilateral ECT group had a larger HDRS-17 score reduction during treatment (ECT: 18.24 +/- 1.18; non-ECT: 14.20 +/- 0.76; p = 0.004). There were no significant differences in response and remission rates between groups. Unilateral ECT group had longer mean duration of hospitalization in days (ECT: 35.48 +/- 2.48; non-ECT: 24.57 +/- 1.50; p < 0.001), but there were no difference in mean time of treatment (ECT group: 27.66 +/- 1.95; non-ECT: 24.57 +/- 1.50; p = 0.25). Conclusions: Unilateral high-dose ECT is still a useful treatment option, in the real world clinical practice, to reduce the intensity of depressive symptoms in highly depressed inpatients.
- 出版日期2016-11-11
