Does multiple gestation impact birthweight deficit from smoking?

作者：Okah F A^*; Oshodi A A; Liu Y; Cai J

来源：Journal of Perinatology, 2014, 34(2): 112-115.

DOI：10.1038/jp.2013.148

• smoking
• growth restriction
• twin
• pregnancy

OBJECTIVE: To test the hypothesis that the combined birthweight deficit from smoking in twin gestation is significantly greater than previously described for singletons.
STUDY DESIGN: Retrospective cohort study of White/Black live-born twins, 32 to 40 weeks of gestation, 1990 to 2005, Kansas City, MO. Data were analyzed by t-test, chi(2), linear and linear regression analyses.
RESULT: The cohort comprised 1190 twin pairs, 58% Whites and 55% >= 37 weeks. Smoking rate was 14.5% and similar by race (14.2% White vs 14.8%, P = 0.772). The aggregate birthweight of twins of nonsmokers was greater, 5116 g +/- 25 g vs 4870 g +/- 59 g, P<0.001 (mean +/- s.d.) and the difference was 264 g (95% confidence interval, 156 to 372 g) after adjusting for other variables in linear regression analyses.
CONCLUSION: Smoking-associated growth restriction in twins is quantitatively similar to that of singletons. This finding is suggestive of dissipation or a ceiling effect to the growth-restricting effect of cigarette smoking.

• 出版日期2014-2