科研之友
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摘要
Augmentation of the mechanical properties of connective tissue using ultraviolet (UV) radiation-by targeting collagen cross-linking in the tissue at predetermined UV exposure time and wavelength -has been proposed as a therapeutic method for supporting the treatment for structural-related injuries and pathologies. However, the effects of and on the tissue elasticity, namely elastic modulus and modulus of resilience , are not entirely clear. We present a thermomechanical framework to reconcile the - and -related effects on and . The framework addresses (1) an energy transfer model to describe the dependence of the absorbed UV photon energy, , per unit mass of the tissue on and , (2) an intervening thermodynamic shear-related parameter, , to quantify the extent of UV-induced cross-linking in the tissue, (3) a threshold model for the versus relationship, characterized by -the critical underpinning the association of with -and (4) the role of in the tissue elasticity. We hypothesized that regulates (UV-stiffening hypothesis) and (UV-resilience hypothesis). The framework was evaluated with the support from data derived from tensile testing on isolated ligament fascicles, treated with two levels of (365 and 254 nm) and three levels of (15, 30 and 60 min). Predictions from the energy transfer model corroborated the findings from a two-factor analysis of variance of the effects of and treatments. Student%26apos;s t test revealed positive change in and with increases in -the findings lend support to the hypotheses, implicating the implicit dependence of UV-induced cross-links on and for directing tissue stiffness and resilience. From a practical perspective, the study is a step in the direction to establish a UV irradiation treatment protocol for effective control of exogenous cross-linking in connective tissues.
- 出版日期2014-10
- 单位南阳理工学院
