Multicomponent reactions (MCRs) of arylmethyl bromides, arylamidines and elemental sulfur toward unsymmetric 3,5-diaryl 1,2,4-thiadiazoles

作者：Zhou, Zhen; Liu, Miaochang; Sun, Song; Yao, En; Liu, Suqin; Wu, Zhiwen; Yu, Jin-Tao; Jiang, Yan; Cheng, Jiang^*

来源：Tetrahedron Letters, 2017, 58(26): 2571-2573.

DOI：10.1016/j.tetlet.2017.05.061

• Transition-metal free
• Elemental sulfur
• Multicomponent reactions
• 1,2,4-Thiadiazoles

A base-promoted three-component reaction between arylmethyl bromides, arylamidines and elemental sulfur was developed, leading to unsymmetric 3,5-diary1-1,2,4-thiadiazoles in moderate to good yields with chemical diversity and complexity. This procedure shows broad substrates scope by employing elemental sulfur and commercially available starting materials under transition-metal free conditions.

• 出版日期2017-6-28
• 单位常州大学; 温州大学