Dual-mode endomicroscopy for detection of epithelial dysplasia in the mouth: a descriptive pilot study

作者：Bodenschatz Nico; Poh Catherine F; Lam Sylvia; Lane Pierre; Guillaud Martial; MacAulay Calum E^*

来源：Journal of Biomedical Optics, 2017, 22(8): 086005.

DOI：10.1117/1.JBO.22.8.086005

• endomicroscopy
• biomedical optics
• fluorescence
• light scattering
• in vivo pathology

Dual-mode endomicroscopy is a diagnostic tool for early cancer detection. It combines the high-resolution nuclear tissue contrast of fluorescence endomicroscopy with quantified depth-dependent epithelial backscattering as obtained by diffuse optical microscopy. In an in vivo pilot imaging study of 27 oral lesions from 21 patients, we demonstrate the complementary diagnostic value of both modalities and show correlations between grade of epithelial dysplasia and relative depth-dependent shifts in light backscattering. When combined, the two modalities provide diagnostic sensitivity to both moderate and severe epithelial dysplasia in vivo. (c) The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

• 出版日期2017-8