Lymphatic vessels clean up your arteries

作者:Fernandez Hernando Carlos*
来源:Journal of Clinical Investigation, 2013, 123(4): 1417-1419.
DOI:10.1172/JCI68657

摘要

Reverse cholesterol transport (RCT) is the pathway by which cholesterol accumulated in peripheral tissues, including the artery wall, is transported to the liver for excretion. There is strong evidence suggesting that interventions that increase macrophage cholesterol efflux and RCT would be anti-atherogenic. In this issue of the JCI, Martel et al. investigate the contribution of lymphatic vasculature to RCT. Their results support the concept that the lymphatic vessel route is critical for RCT from atherosclerotic plaques. Therefore, strategies to improve lymphatic transport might be useful for treating atherosclerotic vascular disease.

  • 出版日期2013-4

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