ALPHA-THALASSEMIA AND BETA-THALASSEMIA AMONG CHINESE CHILDREN IN GUANGXI PROVINCE, PR CHINA - MOLECULAR AND HEMATOLOGICAL CHARACTERIZATION

作者：LIANG R; LIANG S; JIANG NH; WEN XJ; ZHAO JB; NECHTMAN JF; STOMING TA; HUISMAN THJ

来源：British Journal of Haematology, 1994, 86(2): 351-354.

DOI：10.1111/j.1365-2141.1994.tb04738.x

• ALPHA THALASSEMIA
• BETA THALASSEMIA
• CHINA

We have studied nearly 100 patients with beta-thalassaemia major and 60 patients with Hb H disease who were attending the Haematology Clinic of Guangxi Medical College, Treatment of the patients was Limited and only a few patients with beta-thalassaemia major received blood transfusion(s). As a result, the severe anaemia has led to early death at 3-4 years for beta(degrees)-thalassaemia homozygotes, and 8-12 years for beta(+)-thalassaemia homozygotes. Four beta-thalassaemia alleles are responsible for nearly 90% of all beta-thalassaemia chromosomes. This information has resulted in the initiation of a prenatal testing programme at the local level. The patients with Hb H disease maintained a haemoglobin level of 6-10 g/dl and early death was infrequently observed. The --(SEA) deletion was the major type of alpha-thalassemia-l, while three smaller deletions (-2.7, -3.7 and -4.2 kb) and two nondeletional alpha-thalassaemia determinants (Hbs Constant Spring and Quong Sze) were the alpha-thalassaemia-2 types.

• 出版日期1994-2
• 单位广西卫生职业技术学院