Dynamical analysis of a sex-structured Chlamydia trachomatis transmission model with time delay

作者：Sharomi O; Gumel A B^*

来源：Nonlinear Analysis: Real World Applications , 2011, 12(2): 837-866.

DOI：10.1016/j.nonrwa.2010.08.010

• Chlamydia
• Permanence
• Time delay
• Equilibria
• Stability
• Backward bifurcation

The effect of using time delay to model the latency period of Chlamydia trachomatis infection is explored, by designing a deterministic two-sex model for Chlamydia transmission dynamics in a population. The resulting delay differential equation model is shown to undergo the phenomenon of backward bifurcation, where a stable disease-free equilibrium co-exists with one or more stable endemic equilibria when the associated reproduction threshold is less than unity. This phenomenon arises due to the re-infection of individuals who recovered from the disease. Using permanence theory, it is shown that Chlamydia will persist in the population whenever the associated reproduction threshold exceeds unity. It is further shown that long latency period could induce positive (decrease disease burden) or negative (increase disease burden) population-level impact depending on the sign of a certain epidemiological threshold quantity and some other conditions. Furthermore, this study shows that adding a time delay (to model the latency period) does not alter the main equilibrium dynamics (with respect to the effective control or persistence of the disease in the community) of the corresponding non-delayed Chlamydia transmission model considered in our earlier study Sharomi and Gumel (2009) [7].

• 出版日期2011-4