Adjuvant Therapy in Stage I Carcinoma of the Breast: The Influence of Multigene Analyses and Molecular Phenotyping

作者：Schwartz Gordon F^*; Bartelink Harry; Burstein Harold J; Cady Blake; Cataliotti Luigi; Fentiman Ian S; Holland Roland; Hughes Kevin S; Masood Shahla; McCormick Beryl; Palazzo Juan A; Pressman Peter I; Reis Filho Jorge; Pusztai Lajos; Rutgers Emiel J T; Seidman Andrew D; Solin Lawrence J; Sparano Joseph A

来源：Breast Journal, 2012, 18(4): 303-311.

DOI：10.1111/j.1524-4741.2012.01264.x

• adjuvant therapy
• breast carcinoma
• estrogen receptors
• gene analysis
• Her-2-neu
• progesterone receptors
• Ki-67

A consensus conference was held in order to provide guidelines for the use of adjuvant therapy in patients with Stage I carcinoma of the breast, using traditional information, such as tumor size, microscopic character, Nottingham index, patient age and co-morbidities, but also incorporating steroid hormone and Her-2-neu data as well as other immunohistochemical markers. The role of the genetic analysis of breast cancer and proprietary gene prognostic signatures was discussed, along with the molecular profiling of breast cancers into several groups that may predict prognosis. These molecular data are not currently sufficiently mature to make them part of decision making algorithms of recommendations for the treatment of individual patients.

• 出版日期2012-8