Nucleophilic-Bisphosphine-Catalysed One-Pot Sequential [4+2]/[4+2] Annulation of an Allenoate with Benzylidenepyrazolones

作者：Jia, Yu; Tang, Xiao; Cai, Guowei; Jia, Ruxuan; Wang, Boran; Miao, Zhiwei^*

来源：European Journal of Organic Chemistry, 2015, 2015(21): 4720-4725.

DOI：10.1002/ejoc.201500399

• Synthetic methods
• Annulation
• Spiro compounds
• Nitrogen heterocycles

An efficient bisphosphine-catalysed sequential [4+2]/[4+2] annulation reaction of a -benzyl allenoate with benzylidenepyrazolones has been developed. Under the catalysis of DPPB [1,3-bis(diphenylphosphanyl)butane], the [4+2]/[4+2] annulation proceeded smoothly to give spiro-pyrazolidinone derivatives in moderate yields. This protocol provides a simple and practical strategy for the construction of highly substituted 2H-spiro[naphthalene-pyrazole] skeletons.

• 出版日期2015-7
• 单位南开大学