Drug-Induced Hypersensitivity Syndrome by Triple Therapy of Peginterferon Alpha2b, Ribavirin and Telaprevir in Double-Positive Patient for HBV and HCV

作者：Takagi Hitoshi^*; Hoshino Takashi; Naganuma Atsushi; Koitabashi Eri; Uehara Sanae; Sakamoto Naomi; Kudo Tomohiro; Ryusaki Keiichirou; Kakizaki Satoru; Okamoto Hiroaki

来源：Hepato-Gastroenterology, 2013, 60(127): 1557-1560.

DOI：10.5754/hge.13330

• HCV
• HBV
• Interferon
• Telaprevir
• DIHS

Sixty year-old male positive for both HCV-RNA and HBsAg was treated by triple therapy of peginterferon alpha2b, ribavirin and telaprevir. Eight weeks after the beginning of the therapy, the patient developed drug induced hypersensitivity syndrome (DIHS) with general erythema multiforme and 64 times anti-HHV6 antibody elevation. Sixty milligram of prednisolone was administered with gradual dose reduction and the skin lesion was improved. HBV-DNA and transaminase elevated one week after the steroid induction and entecavir improved them. DIHS itself and the aggravation of hepatitis B by corticosteroid should be kept in mind in cases with dual infection of HBV and HCV treated by antivirals including telaprevin

• 出版日期2013-10