A self-immobilizing and fluorogenic unnatural amino acid that mimics phosphotyrosine

作者:Ge Jingyan; Li Lin; Yao Shao Q*
来源:Chemical communications, 2011, 47(39): 10939-10941.
DOI:10.1039/c1cc14653j

摘要

Synthesis of the first self-immobilizing, fluorogenic unnatural amino acid that mimics phosphotyrosine (pTyr) is reported. By using solid-phase peptide synthesis, it was subsequently incorporated into peptide-based probes which found applications in bioimaging and fluorescence-activated cell sorting (FACS).

  • 出版日期2011