Neocryptolepine (Cryprotackieine), A Unique Bioactive Natural Product: Isolation, Synthesis, and Profile of Its Biological Activity

作者：Bracca Andrea B J; Heredia Daniel A; Larghi Enrique L; Kaufman Teodoro S^*

来源：European Journal of Organic Chemistry, 2014, 2014(36): 7979-8003.

DOI：10.1002/ejoc.201402910

• Total synthesis
• Natural products
• Medicinal chemistry
• Alkaloids
• Nitrogen heterocycles
• Cyclization

The widely varying different approaches to the total synthesis of the indoloquinoline alkaloid neocryptolepine are discussed. Aspects relating to the isolation of the natural product from Cryptolepis sanguinolenta, as well as its performance in various biological tests and spectroscopic studies involving the natural product, are also reviewed.

• 出版日期2014-12