A neuronal transmembrane protein LRFN4 induces monocyte/macrophage migration via actin cytoskeleton reorganization

作者：Konakahara Shu^*; Saitou Maki; Hori Shunsuke; Nakane Taku; Murai Kenko; Itoh Reiko; Shinsaka Aya; Kohroki Junya; Kawakami Takao; Kajikawa Masunori; Masuho Yasuhiko

来源：FEBS Letters, 2011, 585(14): 2377-2384.

DOI：10.1016/j.febslet.2011.06.011

• Leucine-rich repeat protein
• Monocytes/macrophages
• Cell migration
• Actin cytoskeleton reorganization

Leucine-rich repeat and fibronectin type III domain-containing (LRFN) family proteins are thought to be neuronal-specific proteins that play essential roles in neurite outgrowth and synapse formation. Here, we focused on expression and function of LRFN4, the fourth member of the LRFN family, in non-neural tissues. We found that LRFN4 was expressed in a wide variety of cancer and leukemia cell lines. We also found that expression of LRFN4 in the monocytic cell line THP-1 and in primary monocytes was upregulated following macrophage differentiation. Furthermore, we demonstrated that LRFN4 signaling regulated both the transendothelial migration of THP-1 cells and the elongation of THP-1 cells via actin cytoskeleton reorganization. Our data indicate that LRFN4 signaling plays an important role in the migration of monocytes/macrophages.

• 出版日期2011-7-21