APOE polymorphism and carotid atherosclerosis in Korean population: The Dong-gu Study and the Namwon Study

作者：Shin Min Ho; Choi Jin Su; Rhee Jung Ae; Lee Young Hoon; Nam Hae Sung; Jeong Seul Ki; Park Kyeong Soo; Kim Hye Yeon; Ryu So Yeon; Choi Seong Woo; Kim Hee Nam; Song Hye Rim; Cauley Jane A; Kweon Sun Seog^*

来源：Atherosclerosis, 2014, 232(1): 180-185.

DOI：10.1016/j.atherosclerosis.2013.11.027

• Apolipoprotein E
• Polymorphism
• Carotid artery plaque
• Intima-media thickness

Objective: We evaluated the association between APOE polymorphism and carotid atherosclerosis in two large independent cohorts from South Korea. %26lt;br%26gt;Methods: The datasets were from the Dong-gu Study (N = 9056) and the Namwon Study (N = 10,158). Carotid ultrasonography was performed to measure carotid intima-media thickness (IMT) and the presence of carotid plaques. The APOE polymorphism was determined by PCR-RFLP. We performed combined and separate analyses for the two datasets. %26lt;br%26gt;Results: In the combined analysis, individuals with E2E2 or E2E3 genotype had a lower common carotid IMT compared with individuals with E3E3 genotype (0.684 mm vs. 0.736 mm, p = 0.007; 0.718 mm vs. 0.736 mm, p %26lt; 0.001, respectively). This association was very slightly attenuated but remained statistically significant after adjustment for blood lipids (0.690 mm vs. 0.736 mm, p = 0.033; 0.725 mm vs. 0.736 mm, p = 0.005, respectively). Compared with individuals with E3E3 genotype, individuals with E2E3 genotype had lower risk for carotid plaque (odds ratio (OR) = 0.83, 95% confidence interval (CI) = 0.75-0.93), while individuals with E3E4 genotype had a higher risk for carotid plaque (OR = 1.09, 95% CI = 1.00-1.20). After adjustment for blood lipids, ORs of E2E3 genotype for carotid plaque was slightly attenuated but remained significant (OR = 0.87 95% CI = 0.78-0.97), while OR of E3E4 genotype were slightly attenuated and not significant (OR = 1.08, 95% CI, = 0.99-1.18). %26lt;br%26gt;Conclusions: We found that APOE polymorphism is associated with carotid atherosclerosis and this association was partly mediated through blood lipid. Our results suggest that APOE polymorphism may influence atherosclerosis through non-lipid pathways.

• 出版日期2014-1