A combined gamma frailty and normal random-effects model for repeated, overdispersed time-to-event data

作者：Molenberghs Geert^*; Verbeke Geert; Efendi Achmad; Braekers Roel; Demetrio Clarice G B

来源：Statistical Methods in Medical Research, 2015, 24(4): 434-452.

DOI：10.1177/0962280214520730

• exponential model
• generalized Cauchy distribution
• conjugacy
• maximum likelihood
• frailty model
• pseudo-likelihood
• strong conjugacy
• Weibull model

This paper presents, extends, and studies a model for repeated, overdispersed time-to-event outcomes, subject to censoring. Building upon work by Molenberghs, Verbeke, and Demetrio (2007) and Molenberghs etal. (2010), gamma and normal random effects are included in a Weibull model, to account for overdispersion and between-subject effects, respectively. Unlike these authors, censoring is allowed for, and two estimation methods are presented. The partial marginalization approach to full maximum likelihood of Molenberghs etal. (2010) is contrasted with pseudo-likelihood estimation. A limited simulation study is conducted to examine the relative merits of these estimation methods. The modeling framework is employed to analyze data on recurrent asthma attacks in children on the one hand and on survival in cancer patients on the other.

• 出版日期2015-8