科研之友
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摘要
The asymmetric organocatalytic conjugate addition-cyclization reaction of malonates with o-hydroxycinnamaldehydes, which affords 4-substituted chroman-2-ols, has been established using a diphenylprolinol trimethylsilyl (TMS) ether as organocatalyst. The desired products were obtained with good to excellent yields and high enantioselectivities (up to >99% ee). Synthetically useful chroman derivatives were formed after subsequent reactions.
- 出版日期2011-10
