A Rare Cause of a Relatively Common Neonatal Emergency

作者:Guran Tulay*; Karasu Gulsun Tezcan; Degirmenci Serpil; Say Aysu; Guran Omer; Paketci Ahu Turkoz; Kornak Uwe
来源:Pediatric Hematology and Oncology, 2012, 29(4): 365-367.
DOI:10.3109/08880018.2011.630441

摘要

Malignant infantile osteopetrosis (MIOP) is a rare cause in the list of etiological factors of neonatal hypocalcemia in several textbooks. The most severe complication of MIOP is bone marrow suppression. The abnormal expansion of bone interferes with medullary haematopoiesis. Most children with this disease die within the first decade of life of secondary consequence of bone marrow failure. Hematopoietic stem cell transplantation (HSCT) is the only curative therapy for MIOP, an otherwise fatal disease. We present a neonate with MIOP that was further complicated with vitamin D deficiency.

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