A red-shifted two-photon-only caging group for three-dimensional photorelease

作者：Becker Yvonne; Unger Erik; Fichte Manuela A H; Gacek Daniel A; Dreuw Andreas; Wachtveitl Josef; Walla Peter J; Heckel Alexander^*

来源：Chemical Science, 2018, 9(10): 2797-2802.

DOI：10.1039/c7sc05182d

Based on nitrodibenzofuran (NDBF) a new photocage with higher two-photon action cross section and red-shifted absorption was developed. Due to calculations, a dimethylamino functionality (DMA) was added at ring position 7. The uncaging of nucleobases after two-photon excitation (2PE) could be visualized via double-strand displacement in a hydrogel. With this assay we achieved three-dimensional photorelease of DMA-NDBF-protected DNA orthogonal to NDBF-protected strands. While being an excellent 2P-cage, DMA-NDBF is surprisingly stable under visible-light one-photon excitation (1PE). This case of excitation-specific photochemistry enhances the scope of orthogonal photoregulation.

• 出版日期2018-3-14