A mild and general method for preparation of alpha-glycosyl chlorides

作者：Chang Chih Wei; Chang Shih Sheng; Chao Chin Sheng; Mong Kwok Kong T^*

来源：Tetrahedron Letters, 2009, 50(31): 4536-4540.

DOI：10.1016/j.tetlet.2009.05.077

A mild and efficient chlorination method for production of glycosyl chlorides is first described which employs inexpensive trichlorotriazine (TCT) and DMF as a chlorination reagent and is compatible with typical acid-labile hydroxyl protecting functions. The scope and limitations, reaction mechanism and its application in the sequential glycosylations are discussed.

• 出版日期2009-8-5