A novel, one-pot, solvent-, and catalyst-free synthesis of 2-aryl/alkyl-4(3H)-quinazolinones

作者：Adib Mehdi^*; Ansari Samira; Mohammadi Ali; Bijanzadeh Hamid Reza

来源：Tetrahedron Letters, 2010, 51(1): 30-32.

DOI：10.1016/j.tetlet.2009.06.034

• Anthranilic acids
• Nitriles
• Amidoximes
• 2-Aryl/alkyl-4(3H)-quinazolinones
• Solvent-free
• Catalyst-free

A novel and one-pot synthesis of 2-aryl/alkyl-4(3H)-quinazolinones is described. The in situ prepared amidoximes from the reaction between nitriles and hydroxylamine are condensed with anthranilic acids under solvent- and catalyst-free conditions to produce the title compounds in excellent yields.

• 出版日期2010-1-6