A weighted scoring system to differentiate malignant liposarcomas from benign lipomas

作者：Wang, Shiyao; Chan, Lester Wai Mon; Tang, Xiaodong; Su, Chang; Zhang, Chunfang; Sun, Kunkun; Shen, Danhua; Chen, Hao; Guo, Wei^*

来源：Journal of Orthopaedic Surgery, 2016, 24(2): 216-221.

DOI：10.1177/1602400219

• lipoma
• liposarcoma

Purpose. To construct a scoring system to differentiate malignant liposarcomas from benign lipomas by comparing their clinical and magnetic resonance imaging (MRI) features. @@@ Methods. Clinical and MRI features of 33 women and 33 men aged 17 to 83 (mean, 53) years who underwent resection of malignant liposarcomas (n=32) or benign lipomas (n=34) were reviewed. @@@ Results. The 5 strongest predictors of liposarcoma were male gender, larger tumour maximum dimension, deep to fascia, thick non-fatty septum or nodule, and internal cystic change. A weighted scoring system was constructed using the 5 strongest predictors as: Z score=10X(1)-FX2+12X(3)+15X(4)+10X(5), respectively. A cut-off score of 35 was used; all 32 malignant liposarcomas and 4 of 34 benign lipomas scored >35. The cut-off score of <= 35 could predict 30 of 66 lipomatous tumours as benign with a negative predictive value of 100% (p<0.0001). @@@ Conclusion. The 5 strongest clinical and MRI features were identified to construct a scoring system to differentiate malignant from benign lipomatous tumours. Further validation in independent populations is required.

• 出版日期2016-8
• 单位北京大学