Preparation of 1,4-disubstituted-1,2,3-triazolo ribonucleosides by Na2CuP2O7 catalyzed azide-alkyne 1,3-dipolar cycloaddition

作者：Elayadi Hanane; Mesnaoui Mohamed; Korba Brent E; Smietana Michael; Vasseur Jean Jacques; Secrist John A; Lazrek Hassan B^*

来源：ARKIVOC, 2012, 76-89.

• 1,2,3-Triazolo ribonucleosides
• Na2CuP2O7
• click chemistry

In this study, we describe the synthesis of 1,4-disustituted-1,2,3-triazolo-ribonucleosides by means of 1,3-dipolar cycloaddition between various N-1 propargyl-pyrimidines and 1%26apos;-azido2%26apos;, 3%26apos;, 5%26apos;-tri-O-benzoylribose catalyzed by Na2CuP2O7/sodium ascorbate. All obtained compounds were evaluated for their anti-HCV activity in vitro.

• 出版日期2012