Mst Out and HCC In

作者：Zhao Bin; Lei Qunying; Guan Kun Liang^*

来源：Cancer Cell, 2009, 16(5): 363-364.

DOI：10.1016/j.ccr.2009.10.008

Mst1 and Mst2 are key components of the Hippo tumor suppressor pathway. In this issue, Zhou et al. (2009) reported that Mst1/2 ablation leads to hepatocellular carcinomas. Unexpectedly, Mst1/2 may activate another kinase besides Lats1 and Lats2 to phosphorylate YAP, and the role of Mst1/2 in YAP regulation is cell type dependent.

• 出版日期2009-11-3
• 单位复旦大学