A new regioselective synthesis and bioactivity of 1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one derivatives

作者:Wang, HQ; Liu, ZJ*; Yang, LM; Ding, MW
来源:Journal of Heterocyclic Chemistry, 2004, 41(3): 393-397.
DOI:10.1002/jhet.5570410314

摘要

A series of new1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one Derivatives 5 has been designed and regioselectively synthesized via a tandem aza-Wittig reaction. The structures of all compounds prepared have been confirmed by H-1 NMR, IR, EI-MS spectroscopy and elemental analyses. The results of preliminary bioassay indicate that most compounds 5 possess an inhibition effect against Botrytis cinereapers and Pyricularia oryzae at the concentration of 50 mg/L.