Monitoring for Human Papillomavirus Vaccine Impact Among Gay, Bisexual, and Other Men Who Have Sex With Men-United States, 2012-2014

作者：Meites Elissa; Gorbach Pamina M; Gratzer Beau; Panicker Gitika; Steinau Martin; Collins Tom; Parrish Adam; Randel Cody; McGrath Mark; Carrasco Steven; Moore Janell; Zaidi Akbar; Braxton Jim; Kerndt Peter R; Unger Elizabeth R; Cro**y Richard A; Markowitz Lauri E

来源：Journal of Infectious Diseases, 2016, 214(5): 689-696.

DOI：10.1093/infdis/jiw232

• epidemiological monitoring
• homosexuality
• male
• papillomavirus infections
• papillomavirus vaccines

Background. Gay, bisexual, and other men who have sex with men (MSM) are at high risk for human papillomavirus (HPV) infection; vaccination is recommended for US males, including MSM through age 26 years. We assessed evidence of HPV among vaccine- eligible MSM and transgender women to monitor vaccine impact.
Methods.aEuro integral During 2012-2014, MSM aged 18-26 years at select clinics completed a computer-assisted self-interview regarding sexual behavior, human immunodeficiency virus (HIV) status, and vaccinations. Self-collected anal swab and oral rinse specimens were tested for HPV DNA (37 types) by L1 consensus polymerase chain reaction; serum was tested for HPV antibodies (4 types) by a multiplexed virus-like particle-based immunoglobulin G direct enzyme-linked immunosorbent assay.
Results.aEuro integral Among 922 vaccine-eligible participants, the mean age was 23 years, and the mean number of lifetime sex partners was 37. Among 834 without HIV infection, any anal HPV was detected in 69.4% and any oral HPV in 8.4%, yet only 8.5% had evidence of exposure to all quadrivalent vaccine types. In multivariate analysis, HPV prevalence varied significantly (P < .05) by HIV status, sexual orientation, and lifetime number of sex partners, but not by race/ethnicity.
Discussions.aEuro integral Most young MSM lacked evidence of current or past infection with all vaccine-type HPV types, suggesting that they could benefit from vaccination. The impact of vaccination among MSM may be assessed by monitoring HPV prevalence, including in self-collected specimens.

• 出版日期2016-9-1